James Chambers has put collectively a sequence of papers well being beneficial properties (and price effectiveness) utilizing the Tufts Value Effectiveness Evaluation Registry. In these research , he finds that remedies for uncommon ailments, specialty medication, and those who obtain expedited overview are extra possible to offer the biggest well being profit (≥0.9 QALYs gained versus comparator).
Chambers et al. (2020) exhibits that is true for remedies for uncommon illness:
Chambers et al. (2017) exhibits that is true for remedies receiving expedited overview:
and Chambers et al. (2014) exhibits that that is true for specialty medication.
Notice that the bigger well being beneficial properties are sometimes correlated with greater drug costs. Within the case of uncommon illness, these extremely useful remedies are much less prone to be price efficient, on account of excessive therapy price. This shouldn’t be shocking, nonetheless, as greater costs are wanted to fund R&D efforts since–by definition–market sizes are smaller for uncommon ailments. Then again the Chambers et al. (2014) research exhibits that whereas specialty medication price extra, price effectiveness is akin to conventional medication as a result of well being beneficial properties are greater on common.